Biology of bacterial deoxyribonucleic acid topoisomerases.

INTRODUCTION .......................................................................... DNA SUPERCOILING AND TOPOISOMERASES ............................................. CONTROL OF TOPOISOMERASE GENE EXPRESSION ...................................... ROLE OF TOPOISOMERASES AND SUPERCOILING IN DNA REPLICATION................. Elongation Phase of Replication ............................................................ Initiation of Replication ................................................................... Termination of Replication ................................................................ Plasmid Replication In Vivo ............................................................... ROLE OF TOPOISOMERASES AND SUPERCOILING IN GENE EXPRESSION................. CELLULAR RESPONSES TO NALIDIXIC ACID............................................. TOPOISOMERASES, RECOMBINATION, AND REPAIR ...................................... Generalized Recombination. .. ............................................................ Site-Specific Recombination. .. ............................................................ Gyrase-Mediated Illegitimate Recombination. .. ............................................. DNA Repair............................................................................ CONCLUDING REMARKS ................................................................. ACKNOWLEDGMENTS .................................................................... LITERATURE CITED..................................................................... 273 274 276 277 277 279 279 280 280 281 282 282 282 283 284 285 285 285